Main Sequence

The systems the world runs on — energy, food, health, compute, industry and space — are being rebuilt. We back the founders doing it.

We’re Australia’s deep tech venture firm, built out of CSIRO, the national science agency, with deep ties to every major university in the country. For eight years we’ve been standing on this frontier, not naming it from the sidelines.

$1B+ under management. Three funds, two top-quartile. 77+ companies, including two unicorns — Gilmour Space and Advanced Navigation — with more emerging.

Nearly half our portfolio was created in-house, through three proprietary engines: Spinouts (commercialising research from leading institutions), Venture Science (our company-creation playbook), and Atmosphere (our dedicated pre-seed fund).